IP-10/MCP-1 ratio in CSF is an useful diagnostic marker of neuropsychiatric lupus patients.

¼ severe and non-weight-bearing arthritis. Each limb was graded, resulting in a maximum clinical score of 20 per animal, as described previously [10]. For histological evaluation, we performed haematoxylin and eosin staining of tissue specimens of the ankle. Ethical approval was not required for this study as it was an entrusted work by Nihon Bioresearch. The Mann–Whitney U-test was used to compare non-parametric data for statistical significance. As shown in Fig. 1, TAK-779 suppressed the progression of clinical arthritis compared with control rats treated with PBS, as demonstrated by paw volume and arthritis score (Fig. 1A). In TAK-779-treated rats, statistically significant effects were observed with higher doses (P<0.01). By day 18, histological analysis of the ankle joint in rats treated with TAK-779 at 1 mg/kg/day, rats treated with TAK-779 at 2 mg/kg/day and control rats (PBS) show that TAK-779 inhibited mononuclear cell infiltration and pannus formation in synovial tissue (Fig. 1B). Histology of a normal rat joint at this age is also shown in Fig. 1B. There was no mortality and no body weight loss in TAK-779-treated rats. These data suggest that TAK-779 has anti-arthritis effects in vivo. These results further support the evidence shown by others that CCR5 plays an important role in the development of arthritis in animal models of human RA. Taken together, the results show that therapy with CCR5 antagonists may serve as a new strategy for the treatment of RA. The authors have declared no conflicts of interest. A non-peptide CCR5 antagonist inhibits collagen-induced arthritis by modulating T cell migration without affecting anti-collagen T cell responses. Inhibition of the development of collagen-induced arthritis in rhesus monkeys by a small molecular weight antagonist of CCR5. Expression of the cytokine RANTES in human rheumatoid synovial fibroblasts. Differential regulation of RANTES and interleukin-8 genes by inflammatory cytokines. and regulation of regulated on activation, normal T cells expressed and secreted in thyroid tissue of patients with Graves' disease and thyroid autonomy and in thyroid-derived cell populations. A small-molecule, nonpeptide CCR5 antagonist with highly potent and selective anti-HIV-1 activity. Inhibition of NF-kappaB signaling by fenofibrate, a peroxisome proliferator-activated receptor-alpha ligand, presents a therapeutic strategy for rheumatoid arthritis. IP-10/MCP-1 ratio in CSF is an useful diagnostic marker of neuropsychiatric lupus patients SIR, Neuropsychiatric syndromes of systemic lupus erythematosus (NPSLE) is one of the major causes of morbidity and mortality in patients with systemic lupus erythematosus (SLE). NPSLE has been reported to …